Why does caffeine cause a crash?

Caffeine is a natural stimulant that is commonly consumed in coffee, tea, and energy drinks. It can improve alertness and concentration, and has been shown to improve physical performance in athletes. However, it's important to note that consuming large amounts of caffeine can have negative side effects, such as anxiety, jitteriness, and sleep disturbances.

Caffeine interacts with adenosine receptors in the brain in a unique way that leads to its stimulating effects. Adenosine is a naturally occurring chemical in the brain that acts as a neurotransmitter and plays a role in promoting sleep and suppressing arousal. Adenosine works by binding to specific receptors in the brain, including A1 and A2A adenosine receptors.

Caffeine is structurally similar to adenosine and can bind to adenosine receptors in the brain. However, caffeine does not activate the receptors in the same way that adenosine does. Instead, caffeine blocks the action of adenosine by occupying the receptor sites without activating them. This leads to an increase in neuronal activity and the release of neurotransmitters such as dopamine and norepinephrine, which produce the stimulating effects of caffeine. When caffeine exits the body, adenosine receptors supercharge and cause fatigue faster than normal, hence, a caffeine crash.

Over time, the brain responds to regular caffeine consumption by increasing the number of adenosine receptors to compensate for the blockade of receptors by caffeine. This can lead to a decrease in the effectiveness of caffeine in producing its stimulating effects, and can also contribute to the development of caffeine dependence and withdrawal symptoms when caffeine consumption is reduced or discontinued.

B12 is an essential vitamin that plays a role in the production of red blood cells and the functioning of the nervous system. It is also important for energy metabolism, and some studies have suggested that B12 supplementation may improve energy levels and reduce fatigue.

When consumed together, B12 and caffeine may have a synergistic effect on energy and focus. B12 is involved in energy metabolism, and caffeine can enhance the body's ability to use stored energy. Some research suggests that combining B12 and caffeine may lead to greater improvements in mood, mental clarity, and cognitive function than consuming caffeine alone.

Additionally, B12 and caffeine should not be relied on as a long-term solution for low energy levels or other health issues. It's always a good idea to consult with a healthcare professional before taking any dietary supplements or making significant changes to your diet.

NextDay uses far less caffeine than energy drinks (48.5mg per serving or about a Diet Coke's worth) but combines it with B12 for an anytime pick-me-up without the jitters or a crash. Not to mention all the unique properties for dealing specifically with hangovers!

Find more about caffeine and it's positive and negatives effects from Standard research Andrew Huberman.